Victory would move Town further away from the bottomSteven Pressley is hoping his players can maintain the same spirit levels as they showed in midweek when they make the trip to Roots Hall on Saturday.
Town take on 10th place Southend United knowing they can extend the gap between them and the teams below them at the foot of the table with a win.
Fleetwood will travel to Essex in confident mood after Tuesday’s deserved 2-0 victory over Graham Wesley’s Peterborough outfit at Highbury.
Ahead of the game, Pressley said: “Tuesday was up there with one of the best performances I’ve seen from us this season. The players deserved so much credit because they worked so hard.
“There was a great spirit about the group and I was really pleased with us. The unfortunate thing about football in England is that you can’t really enjoy your victories!
“We have to focus now on Southend because it’s a big weekend of football for the bottom sides. There’s a lot of important fixtures in that respect.
“We’re all fighting for our lives and it’s very, very close in that area. There has been certain years where 48 points has kept teams up, but it doesn’t look like that this year.
“It’s going to be a really tense end to the season but we have to just take care of ourselves and go about our business like we did on Tuesday.”
Pressley admits he knows the task ahead of his side this weekend as they aim to topple a United side who have a strong home record.
“Southend have been disappointing away from home but they’ve been strong at home and have only lost once in their last six at Roots Hall.
“They’ve won three of those and are a very aggressive home team. It’s a tight little stadium which generates a really good atmosphere within the ground.
“It’ll be what I expect which will be an aggressive side who ask questions of you defensively as they like to put you under pressure.
“They’re very good at doing that and it’s going to take a Tuesday type performance and more to get a positive result. That’s what we’re focused on.”